Two previous investigations were performed to assess the activity of Gelsemium sempervirens (Gelsemium s.) in mice, using\r\nemotional response models. These two series are pooled and analysed here. Gelsemium s. in various homeopathic centesimal\r\ndilutions/dynamizations (4C, 5C, 7C, 9C, and 30C), a placebo (solvent vehicle), and the reference drugs diazepam (1 mg/kg body\r\nweight) or buspirone (5 mg/kg body weight) were delivered intraperitoneally to groups of albino CD1 mice, and their effects on\r\nanimal behaviour were assessed by the light-dark (LD) choice test and the open-field (OF) exploration test. Up to 14 separate\r\nreplications were carried out in fully blind and randomised conditions. Pooled analysis demonstrated highly significant effects of\r\nGelsemium s. 5C, 7C, and 30C on the OF parameter ââ?¬Å?time spent in central areaââ?¬Â and of Gelsemium s. 5C, 9C, and 30C on the\r\nLD parameters ââ?¬Å?time spent in lit areaââ?¬Â and ââ?¬Å?number of light-dark transitions,ââ?¬Â without any sedative action or adverse effects on\r\nlocomotion. This pooled data analysis confirms and reinforces the evidence that Gelsemium s. regulates emotional responses and\r\nbehaviour of laboratory mice in a nonlinear fashion with dilution/dynamization.
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